Effects of Propofol Anaesthesia on Thermoregulation, Blood Constituents, Coagulation Indices and Selected Serum Biochemicals and Enzymes in Pregnant Rabbit Model
Published: 2020-05-01
Page: 107-126
Issue: 2019 - Volume 2 [Issue 1]
Khalid Abbas Owish Sukar *
Faculty of Medicine, University of Bakht Alruda, P.O. Box 1311, El-duiam-12556, Khartoum, Sudan.
Abdalla Mohamed Abdelatif
Faculty of Veterinary Medicine, University of Khartoum, Sudan.
Etayeb Mohamed Alfaki
Faculty of Medicine, University of Bakht Alruda, P.O. Box 1311, El-duiam-12556, Khartoum, Sudan.
*Author to whom correspondence should be addressed.
Abstract
Aim: This study was conducted to evaluate the effects of propofol anaesthetic on the physiological responses in rabbit model in mid gestation (GD18) period.
Methods: Fourteen rabbits, 7 pregnant and 7 nonpregnant were used in this study. Both groups were induced propofol anaesthetic intravenously maintained for 90 min by constant I.V infusion rate (1mg/kg/min). Measurements of the parameters were performed before and after induction of anaesthesia for pregnant and nonpregnant rabbits.
Results: The RR and HR decreased significantly (P 0.05) after propofol anaesthesia in pregnant and nonpregnant rabbits. The PCV, Hb and erythrocytes values were significantly (P<0.05) lower after propofol anaesthesia in both groups. Interactions between pregnancy and propofol anaesthesia indicated a decrease in RR, PCV, MCV and increases in PT, serum levels of Na+, K+, plasma Osmolality, LDH and CPK enzymes.
Conclusions: The studies provide evidence that pregnancy induces variable alterations in blood profiles in anaesthetized rabbits.
Keywords: Rabbits, propofol, pregnancy, haemetological parameters